Hyperandrogenic anovulation (PCOS): A unique disorder of insulin action associated with an increased risk of non-insulin-dependent diabetes mellitus

摘要: Polycystic ovary syndrome is the most common endocrine disorder in women of reproductive age. Recent prevalence estimates suggest that 5–10% premenopausal have full-blown hyperandrogenism, chronic anovulation, and polycystic ovaries. Evidence suggests with a unique insulin action are at increased risk to develop non-insulin-dependent diabetes mellitus. Further, mellitus has substantially earlier age onset (third fourth decades) than it does general population (sixth seventh decades). Studies assessing whether abnormalities intrinsic or secondary hormonal milieu found insulin-induced receptor autophosphorylation markedly diminished approximately 50% women. This defect not seen other insulin-resistant states obesity In who normal autophosphorylation, remains likely signaling mechanisms downstream abnormal, since these also resistant. distinctive post-insulin-binding appears be genetic, present cells removed from vivo environment for generations.