In vivo biocompatibility and biodegradation of poly(ethylene carbonate).

摘要: Abstract Biodegradation and biocompatibility of poly(ethylene carbonate) (PEC) was examined using an in vivo cage implant system. Exudate analysis showed that PEC degradation products were biocompatible induced minimal inflammatory wound healing responses. Adherent foreign body giant cells (FBGCs) caused pitting on the surface, which led to extensive over time. Data obtained from molecular weight examination film cross-sections scanning electron microscope (SEM) indicated underwent surface erosion with no change remaining bulk. Attenuated total reflectance infrared (ATR-FTIR) spectroscopy used characterize chemical degradation. Superoxide anion released appeared initiate “unzipping” mechanism by deprotonation hydroxyl end groups. The resulting alkoxide ion participated a concerted involving water carbonate carbonyl, leading elimination ethylene glycol. Carbonate ions decomposed further release carbon dioxide regenerate ion.