Antioxidant Influence of Aronia melanocarpa Extract after Doxorubicin Treatment in Vitro and in Vivo

摘要: Levels of the intracellular reduced Glutathione (GSH), proved as a result mainly action medical plant Aronia melanocarpa (Black chokeberry) in vitro and vivo, were measured. is one most effective for current use. Although mechanisms toxicity chemotherapeutic agent Doxorubicin (DOX) are not fully cleared, oxidative stress appears to be involved. has been shown possess highest antioxidant activities among fruits. In this connection, study was directed investigation on possible protective effect total extract from medicinal against DOX-induced both vivo. Despite established decrease GSH levels normal 3T3 mouse embryonic fibroblasts, malignant cells mixed cultures presence Doxorubicin, certain regeneration them noticed Aroniaextract. The administration (20 mg/kg i. p.) Balb/c experimental mice caused significant tissue glutathione level liver, heart small intestine. all cases, observed biochemical alterations attenuated pre-treatment with extract. We concluded that due enhancement level, which might have important cell-protective effects Doxorubicin-induced stress. Further vitro- vivo-studies influence separate components GSH, but also GSH-dependent enzymes representing coordinately regulated defense changes, should made.