Is miR-34a a Well-equipped Swordsman to Conquer Temple of Molecular Oncology?

摘要: Overwhelmingly increasing advancements in miRNA biology have opened new avenues for pharmaceutical companies to initiate studies on designing effective, safe, and therapeutically active candidates using mimetics inhibitors. In accordance with this approach, development of miravirsen SPC3649, an LNA-based (locked nucleic acid) antisense molecule against miR-122, treat hepatitis C has sparked interest identifying most efficient microRNAs journey from bench-top toward industry breakthroughs delivery technology will pave the way 'final frontier'. MRX34, a liposome-formulated mimic miR-34 treatment metastatic cancer liver involvement unresectable primary cancer, also entered clinical trial. There is successive increase research work related regulation modulators intracellular signaling cascades. We partition review into how miR-34a regulated by different proteins Wnt- TGF-induced cascades are modulated miR-34a. review, we bring limelight regulates its target genes induce apoptosis inhibit cell proliferation as evidenced vitro vivo analysis. discuss PDGFR c-MET recent nanotechnologically delivered Spotlight set modulation chemotherapeutic sensitivity cells reconstruction studies. Clinical trial indicative tremendous potential, continuous cutting prove be effective efficiently translating laboratory findings clinically therapeutics.