Nitrite Induces the Extravasation of Iron Oxide Nanoparticles in Hypoxic Tumor Tissue

摘要: Nitrite undergoes reconversion to nitric oxide under conditions characteristic of the tumor microenvironment, such as hypoxia and low pH. This selective conversion nitrite into in tissue has led possibility using enhance drug delivery radiation response. In this work, we propose serially characterize vascular response brain tumor-bearing rats contrast-enhanced R2* mapping. Imaging is performed a multi-echo gradient echo sequence at baseline, post iron nanoparticle injection post-nitrite injection, whilst animal breathing air. The results indicate that sufficiently increases permeability C6 gliomas, nanoparticles accumulate within tissue. When animals breathed 100% oxygen, contrast agent remained vasculature, indicating occurs presence tumor. hypoxia-dependent, nitrite-induced extravasation observed herein implications for enhancement conventional nanotherapeutic delivery. Copyright © 2014 John Wiley & Sons, Ltd.