NFATs and Alzheimer's Disease.
作者： Jennifer L Furman , Diana M Mathis , Christopher M Norris , Hafiz Mohmmad Abdul , Michelle A Sama
DOI:
关键词: Gene isoform 、 Glutamate receptor 、 Transcription factor 、 Phosphatase 、 NFAT 、 Cell biology 、 Nervous tissue 、 Dephosphorylation 、 Bioinformatics 、 Calcineurin 、 Medicine
摘要: Nuclear factor of activated T cells (NFAT) is a transcription that translocates from cytosol to nucleus following dephosphorylation by the Ca(2+)/calmodulin dependent protein phosphatase calcineurin (CN). In nervous tissue, aberrant CN signaling increasingly linked variety pathologic features associated with Alzheimer's disease (AD), including synaptic dysfunction, glial activation, and neuronal death. Consistent this linkage, our recent work on postmortem human hippocampal tissue discovered increased nuclear accumulation select NFAT isoforms at different stages AD. Some these changes occurred early process and/or paralleled diminishing cognitive status. addition, inhibition astrocytic activity in primary cultures neurons glia dampened glutamate levels alleviated death response pathogenic amyloid-β peptides. article, we discuss findings expand upon possible isoform specific contributions NFATs progression We also consider benefits using inhibitors treat AD other neurodegenerative disorders, as well.
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