Mismatch repair system and p53 expression in patients with T1 and T2 colorectal cancer: predictive role of lymph node metastasis and survival.
作者： Jung Wook Huh , Hee Cheol Kim , Seok Hyung Kim , Yoon Ah Park , Yong Beom Cho
DOI: 10.1002/JSO.23592
关键词: Perineural invasion 、 Radical surgery 、 Microsatellite instability 、 Lymph node 、 Medicine 、 Oncology 、 Survival rate 、 Lymphovascular invasion 、 Lymphadenectomy 、 Internal medicine 、 Tumor budding
摘要: Background The aim of this study was to evaluate the predictive role mismatch repair (MMR) system and p53 expression for lymph node metastasis long-term survival in patients with T1 T2 colorectal cancer. Methods A total 543 or cancers who underwent radical surgery regional lymphadenectomy from December 2007 2009 were analyzed. Predictive factors prognostic analyzed. Results During median follow-up period 4 years, 5-year disease-free rate without 94.8%, which significantly higher than that those metastases (85.2%; P < 0.001). On multivariate analysis, gender, tumor location, N category, lymphatic invasion, vascular perineural invasion independent survival; however MMR defect, expression, microsatellite instability (MSI) not. The presence budding predictors metastasis. Conclusions In cancer, metastasis; however, MSI not predictive. J. Surg. Oncol. 2014 109:848–852. © Wiley Periodicals, Inc.
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