Tumor Microsatellite Instability and Clinical Outcome in Young Patients with Colorectal Cancer

摘要: Background Colorectal cancer can arise through two distinct mutational pathways: microsatellite instability or chromosomal instability. We tested the hypothesis that colorectal cancers arising from microsatellite-instability pathway have distinctive clinical attributes affect outcome. Methods specimens of a population-based series 607 patients (50 years age younger at diagnosis) for compared features and survival who had characterized by high-frequency with these characteristics in stability. Results found 17 percent patients, multivariate analysis, was associated significant advantage independently all standard prognostic factors, including tumor stage (haza...