Methylation as a biomarker for head and neck cancer

摘要: Head and neck cancer is a collective term that describes malignant tumors of the oral cavity, pharynx, larynx characterized by high incidence mortality rates. Although most HNSCC originate from mucosal surface upper aerodigestive tract, where they can be easily detected during routine clinical examination. Often definitive diagnosis delayed because difficulty in differentiating other similar lesions. Activation proto-oncogenes inactivation tumor suppressor genes are major molecular alterations involved carcinogenesis. In addition, epigenetic changes alter expression critical important development variety cancers. The detection aberrant gene promoter methylation as tool for or its use prognostic marker have been described many different cancers including HNSCC. search biomarkers has main aim evaluation measurement status normal pathological biological processes well pharmacological responses to certain treatments. tracking these an part identification individuals early stages head diagnostic relevance reflecting survival rates, better quality life less cost healthcare system. Therefore, assuming results genetic changes, analyzes based on profile combination with would useful predicting behavior tumors.