Prognostic Significance of the Number of Lymph Nodes Removed at Lobectomy in Stage IA Non-small Cell Lung Cancer
作者： Sai-Hong Ignatius Ou , Jason A. Zell
DOI: 10.1097/JTO.0B013E31817DFCED
关键词: Lymph 、 Carcinoma 、 Survival rate 、 Cancer registry 、 Medicine 、 Internal medicine 、 Mediastinal lymph node 、 Pneumonectomy 、 Stage (cooking) 、 Surgery 、 Oncology 、 Hazard ratio
摘要: Background Lobectomy with mediastinal lymph node dissection is the standard of care in stage IA non-small cell lung cancer (NSCLC). We investigated whether number nodes removed influences survival NSCLC patients who underwent lobectomy. Methods 2545 California Cancer Registry lobectomy between 1999 and 2003 were analyzed. Cox proportional hazards regression was used to identify independent prognostic factors. Results Increasing associated statistical significant improvements overall (OS) ( p = 0.0001) cancer-specific (LCSS) 0.0309) The remained an favorable factor for OS trend LCSS 0.0095) even after adjustment other factors including age, sex, histology, histologic grade, socioeconomic status, marital status analyses. Removal 11 15 conferred lowest hazard ratio death [versus none; ratio=0.52; 95% confidence interval: 0.36–0.75]. Conclusions LCSS.
jto.org
elsevier.com
sci-hub.se 参考文章(31)
Kathleen Yost, Carin Perkins, Richard Cohen, Cyllene Morris, William Wright, Socioeconomic status and breast cancer incidence in California for different race/ethnic groups. Cancer Causes & Control. ,vol. 12, pp. 703- 711 ,(2001) , 10.1023/A:1011240019516
Ajeet Gajra, Nancy Newman, Gary P. Gamble, Leslie J. Kohman, Stephen L. Graziano, Effect of Number of Lymph Nodes Sampled on Outcome in Patients With Stage I Non–Small-Cell Lung Cancer Journal of Clinical Oncology. ,vol. 21, pp. 1029- 1034 ,(2003) , 10.1200/JCO.2003.07.010
S.-H. Ignatius Ou, Jason A. Zell, Argyrios Ziogas, Hoda Anton-Culver, Low socioeconomic status is a poor prognostic factor for survival in stage I nonsmall cell lung cancer and is independent of surgical treatment, race, and marital status. Cancer. ,vol. 112, pp. 2011- 2020 ,(2008) , 10.1002/CNCR.23397
Didier Lardinois, Hans Suter, Hassan Hakki, Valentin Rousson, Daniel Betticher, Hans-Beat Ris, Morbidity, survival, and site of recurrence after mediastinal lymph-node dissection versus systematic sampling after complete resection for non-small cell lung cancer. The Annals of Thoracic Surgery. ,vol. 80, pp. 268- 275 ,(2005) , 10.1016/J.ATHORACSUR.2005.02.005
Naruyuki Kobayashi, Shinichi Toyooka, Junichi Soh, Kouichi Ichimura, Hiroyuki Yanai, Hiroshi Suehisa, Shuji Ichihara, Masaomi Yamane, Motoi Aoe, Yoshifumi Sano, Hiroshi Date, Risk Factors for Recurrence and Unfavorable Prognosis in Patients with Stage I Non-small Cell Lung Cancer and a Tumor Diameter of 20 mm or Less Journal of Thoracic Oncology. ,vol. 2, pp. 808- 812 ,(2007) , 10.1097/JTO.0B013E31814617C7
Steven M Keller, Sudeshna Adak, Henry Wagner, David H Johnson, Mediastinal lymph node dissection improves survival in patients with stages II and IIIa non-small cell lung cancer The Annals of Thoracic Surgery. ,vol. 70, pp. 358- 365 ,(2000) , 10.1016/S0003-4975(00)01673-8
James Barnard, Joel Dunning, Ghassan Musleh, Nick Odom, Is there a role for the use of radical lymph node dissection in the surgical management of resectable non-small cell lung cancer? Interactive Cardiovascular and Thoracic Surgery. ,vol. 3, pp. 294- 299 ,(2004) , 10.1016/J.ICVTS.2003.12.004
G. J. Chang, M. A. Rodriguez-Bigas, J. M. Skibber, V. A. Moyer, Lymph Node Evaluation and Survival After Curative Resection of Colon Cancer: Systematic Review Journal of the National Cancer Institute. ,vol. 99, pp. 433- 441 ,(2007) , 10.1093/JNCI/DJK092
Kazuro Sugi, Kouichi Nawata, Nobuhiro Fujita, Kazuhiro Ueda, Toshiki Tanaka, Takahisa Matsuoka, Yoshikazu Kaneda, Kensuke Esato, Systematic lymph node dissection for clinically diagnosed peripheral non-small-cell lung cancer less than 2 cm in diameter. World Journal of Surgery. ,vol. 22, pp. 290- 295 ,(1998) , 10.1007/S002689900384
C DODDOLI, A ARAGON, F BARLESI, B CHETAILLE, S ROBITAIL, R GIUDICELLI, P FUENTES, P THOMAS, Does the extent of lymph node dissection influence outcome in patients with stage I non-small-cell lung cancer? European Journal of Cardio-Thoracic Surgery. ,vol. 27, pp. 680- 685 ,(2005) , 10.1016/J.EJCTS.2004.12.035