Pulmonary Vascular Dysfunction

作者: S. J. Finney , S. J. Wort , T. W. Evans

DOI: 10.1007/978-3-642-56107-8_14

关键词: CIRCULATORY FAILUREMedicineSeptic shockCardiologyInternal medicineRespir critHospital patientsInflammatory responsePulmonary hypertensionNitric oxide

摘要: The systemic inflammatory response (SIRS) and its associated syndromes [1] represent formidable problems in critical care medicine, afflicting more than 1% of hospital patients. In 40% cases, circulatory failure or septic shock ensues with an mortality 40–80%, resulting approximately 250, 000 deaths per annum the United States alone [2]. Death is usually attributable to multi-organ dysfunction syndrome (MODS).

参考文章(95)
Shiranee Sriskandan, Jonathan Cohen, GRAM-POSITIVE SEPSIS: Mechanisms and Differences from Gram-Negative Sepsis Infectious Disease Clinics of North America. ,vol. 13, pp. 397- 412 ,(1999) , 10.1016/S0891-5520(05)70082-9
TM Carlos, JM Harlan, Leukocyte-endothelial adhesion molecules. Blood. ,vol. 84, pp. 2068- 2101 ,(1994) , 10.1182/BLOOD.V84.7.2068.BLOODJOURNAL8472068
Ulevitch Rj, Tobias Ps, Pugin J, Activation of endothelial cells by endotoxin: direct versus indirect pathways and the role of CD14. Progress in Clinical and Biological Research. ,vol. 392, pp. 369- ,(1995)
W.J.G. Oyen, T. Hendriks, M.F.C.M. Knapen, F.H.M. Corstens, R.J.A. Goris, G.A.P Nieuwenhuijzen, Organ damage is preceded by changes in vascular permeability in an experimental model of multiple organ dysfunction syndrome. Shock. ,vol. 7, pp. 98- 104 ,(1997)
S. J. H. van Deventer, Cytokine and cytokine receptor polymorphisms in infectious disease. Intensive Care Medicine. ,vol. 26, ,(2000) , 10.1007/S001340051125
N Suttorp, R Spriestersbach, U Sibelius, F Rose, F Grimminger, W Seeger, B Pötzsch, M Meinhardt, S Bhakdi, Human endothelial cell activation and mediator release in response to the bacterial exotoxins Escherichia coli hemolysin and staphylococcal alpha-toxin. Journal of Immunology. ,vol. 159, pp. 1909- 1916 ,(1997)
F. B. Taylor, T. A. Drake, J. Cheng, Al Chang, Expression of tissue factor, thrombomodulin, and E-selectin in baboons with lethal Escherichia coli sepsis. American Journal of Pathology. ,vol. 142, pp. 1458- 1470 ,(1993)
J. Panes, M. A. Perry, D. C. Anderson, A. Manning, B. Leone, G. Cepinskas, C. L. Rosenbloom, M. Miyasaka, P. R. Kvietys, D. N. Granger, Regional differences in constitutive and induced ICAM-1 expression in vivo American Journal of Physiology-heart and Circulatory Physiology. ,vol. 269, ,(1995) , 10.1152/AJPHEART.1995.269.6.H1955
Richard D. Thompson, Matthew W. Wakelin, Karen Y. Larbi, Ann Dewar, George Asimakopoulos, Michael A. Horton, Marian T. Nakada, Sussan Nourshargh, Divergent effects of platelet-endothelial cell adhesion molecule-1 and beta 3 integrin blockade on leukocyte transmigration in vivo. Journal of Immunology. ,vol. 165, pp. 426- 434 ,(2000) , 10.4049/JIMMUNOL.165.1.426
Elena A Levashina, Emma Langley, Clare Green, David Gubb, Michael Ashburner, Jules A Hoffmann, Jean-Marc Reichhart, Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila Science. ,vol. 285, pp. 1917- 1919 ,(1999) , 10.1126/SCIENCE.285.5435.1917