Leukocyte-endothelial adhesion molecules.

摘要: In the 9 years since last review on leukocyte and endothelial interactions was published in this journal many of critical structures involved adherence to migration across endothelium have been elucidated. With advent cell molecular biology approaches, investigations progressed from early descriptions by intravital microscopy histology, functional immunologic characterization adhesion molecules, now development genetically deficient animals first phase I trial "anti-adhesion" therapy humans. The cloning definition adhesive functions integrins, members Ig gene superfamily, selectins has already provided sufficient information construct an operative paradigm basis emigration. regulation these molecules chemoattractants, cytokines, or chemokines, interrelationships pathways need be examined vitro and, particularly, vivo. Additional studies are required dissect contribution individual emigration various models inflammation immune reaction. Certainly, new will identified, current refined. promise insights into pathology inflammatory response, potential for therapies a wide variety diseases assures that continue exciting area investigation.