Cytokine-Mediated Tumor-Endothelial Cell Interaction in Metastasis

摘要: A variety of adhesive interactions take place between tumor cells and host vasculature in progression metastasis (McCormick Zetter 1992; Honn Tang Belloni Tressler 1990). Perhaps one the most important adhesion events process is interaction circulating with endothelium subendothelial matrix (Liotta 1986; Kramer Nicolson 1979). The arrest capillary bed secondary organs, through vascular or lymphatic basement membrane, precedes their migration into tissue parenchyma; once extravasation has occurred, micrometastasis proliferation will start (Crissman et al. 1988). to a necessary step preceding metastatic cells. However, it becoming increasingly clear that preferential microvascular extracellular different areas contributes homing metastases specific organs (Pauli 1990; Auerbach 1987; Pauli Lee 1988; Roos 1984; Attempts identify endothelial cell surface components responsible for organ-specific have been reported (Zhu 1991;