Degradation of Bone and the Role of Osteoclasts, Bone Lining Cells and Osteocytes
作者： Vincent Everts , Paul Saftig
DOI: 10.1007/978-3-642-16861-1_8
关键词: Bone resorption 、 Cathepsin K 、 Bone remodeling 、 Osteoclast 、 Bone healing 、 Cell biology 、 Chemistry 、 Resorption 、 Bone cell 、 Proteolytic enzymes
摘要: Resorption of bone depends on the combined action osteoblast-like lining cells and osteoclasts. The cell plays an essential role in modulating formation osteoclasts mean time prepares surface for these multinucleated resorbing to attach to. osteoclast attaches resorption starts with lowering pH at site, a site that is secluded from rest surrounding environment. lowered results dissolution mineral component, thus exposing matrix. matrix subsequently digested by proteolytic enzymes, among which cysteine proteinase cathepsin K appears be essential. Recent findings indicate not all are alike, different bones may harbour differ several aspects, enzymes used resorption. In this chapter we will discuss steps result degradation bone, onset new deposition presence various sites.
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