Effects of Different Fractions of Whey Protein on Postprandial Lipid and Hormone Responses in Type 2 Diabetes

作者: L S Mortensen , J Holmer-Jensen , M L Hartvigsen , V K Jensen , A Astrup

DOI: 10.1038/EJCN.2012.48

关键词: InsulinGlucagonWhey proteinInternal medicineTriglycerideHydrolysateEndocrinologyMealRetinyl palmitateChemistryPostprandial

摘要: Results: We found no statistical significant differences between meals on our primary variable triglyceride. The retinyl palmitate response was higher after the hydro-meal than after the iso-and lac-meal in the chylomicron-rich fraction (P= 0.008) while no significant differences were found in the chylomicron-poor fraction. The hydro-and iso-meal produced a higher insulin response compared with the lac-and CGMP-meal (P< 0.001). Otherwise no significant differences in the hormone responses were found in the incremental area under …

参考文章(39)
Claus Thomsen, Ole Rasmussen, Thea Lousen, Jens J Holst, Susanne Fenselau, Jürgen Schrezenmeir, Kjeld Hermansen, None, Differential effects of saturated and monounsaturated fatty acids on postprandial lipemia and incretin responses in healthy subjects The American Journal of Clinical Nutrition. ,vol. 69, pp. 1135- 1143 ,(1999) , 10.1093/AJCN/69.6.1135
Jeffrey S. Flier, Lisa H. Underhill, Robert H. Eckel, Lipoprotein lipase. A multifunctional enzyme relevant to common metabolic diseases. The New England Journal of Medicine. ,vol. 320, pp. 1060- 1068 ,(1989) , 10.1056/NEJM198904203201607
Ralph JF Manders, Anton JM Wagenmakers, René Koopman, Antoine HG Zorenc, Paul PCA Menheere, Nicolaas C Schaper, Wim HM Saris, Luc JC van Loon, Co-ingestion of a protein hydrolysate and amino acid mixture with carbohydrate improves plasma glucose disposal in patients with type 2 diabetes. The American Journal of Clinical Nutrition. ,vol. 82, pp. 76- 83 ,(2005) , 10.1093/AJCN.82.1.76
T. Krarup, S. Madsbad, A. J. Moody, L. Regeur, O. K. Faber, J. J. Holst, L. Sestoft, Diminished immunoreactive gastric inhibitory polypeptide response to a meal in newly diagnosed type I (insulin-dependent) diabetics. The Journal of Clinical Endocrinology and Metabolism. ,vol. 56, pp. 1306- 1312 ,(1983) , 10.1210/JCEM-56-6-1306
J. Schrezenmeir, P. Weber, R. Probst, H.K. Biesalski, C. Luley, W. Prellwitz, U. Krause, J. Beyer, Postprandial pattern of triglyceride-rich lipoprotein in normal-weight humans after an oral lipid load: exaggerated triglycerides and altered insulin response in some subjects. Annals of Nutrition and Metabolism. ,vol. 36, pp. 186- 196 ,(1992) , 10.1159/000177717
H. Lithell, J. Boberg, K. Hellsing, G. Lundqvist, B. Vessby, Lipoprotein-lipase activity in human skeletal muscle and adipose tissue in the fasting and the fed states☆ Atherosclerosis. ,vol. 30, pp. 89- 94 ,(1978) , 10.1016/0021-9150(78)90155-7
M.-R. Taskinen, Diabetic dyslipidaemia: from basic research to clinical practice* Diabetologia. ,vol. 46, pp. 733- 749 ,(2003) , 10.1007/S00125-003-1111-Y
Fredrik Karpe, George Steiner, Kristine Uffelman, Thomas Olivecrona, Anders Hamsten, Postprandial lipoproteins and progression of coronary atherosclerosis Atherosclerosis. ,vol. 106, pp. 83- 97 ,(1994) , 10.1016/0021-9150(94)90085-X
J N Matthews, D G Altman, M J Campbell, P Royston, Analysis of serial measurements in medical research. BMJ. ,vol. 300, pp. 230- 235 ,(1990) , 10.1136/BMJ.300.6719.230