A polycationic antimicrobial and biocompatible hydrogel with microbe membrane suctioning ability

摘要: Despite advanced sterilization and aseptic techniques, infections associated with medical implants have not been eradicated. Most present coatings cannot simultaneously fulfil the requirements of antibacterial antifungal activity as well biocompatibility reusability. Here, we report an antimicrobial hydrogel based on dimethyldecylammonium chitosan (with high quaternization)-graft-poly(ethylene glycol) methacrylate (DMDC-Q-g-EM) poly(ethylene diacrylate, which has excellent efficacy against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus Fusarium solani. The proposed mechanism polycationic is by attraction sections anionic microbial membrane into internal nanopores hydrogel, like ‘anion sponge’, leading to disruption then microbe death. We also demonstrated a thin uniform adherent coating simple ultraviolet immobilization. An animal study shows that DMDC-Q-g-EM biocompatible rabbit conjunctiva no toxicity epithelial cells or underlying stroma.