Neuroprotective effects of sea buckthorn leaf extract against hypobaric hypoxia and post-hypoxic reoxygenation induced hippocampal damage in rats.
作者： Govindasamy Ilavazhagan , Satya Narayan Deep , Iswar Baitharu
DOI:
关键词: Hypoxia (medical) 、 GCLC 、 Oxidative stress 、 Biochemistry 、 Biology 、 Oxidative phosphorylation 、 Hippocampal formation 、 Pharmacology 、 Downregulation and upregulation 、 Glutathione 、 Neuroprotection
摘要: Exposure to hypobaric hypoxia (HBH) and reoxygenation (H/R) causes hippocampal neuronal damage leading memory dysfunction mood state alteration. The present study aimed at investigating the potential neuroprotective effect of seabuckthorn leaf extract ((SBTLE)) against HBH induced injury in brain. Six groups male sprague dawley rats were taken exposed simulated equivalent an altitude 7600m animal decompression chamber for 7 days followed by reoxygenation. Rats supplemented with SBTLE (100mg/kgBW) 20 prior during hypoxic exposure. Recovery from injuries following exposure subsequent was carried out separate group animals. Our revealed that stress enhanced oxidative neurons which reversed supplementation. restored Hypoxia/Reoxygenation(H/R) downregulation γ-glutamylcysteine synthetase (GCLC) enzymes responsible glutathione biosynthesis. Post supplementation decreased markers, however, administration conjunction inhibitor GCLC resulted slow recovery H/R injuries. These results provide first evidence induced increase biosynthesis upregulating enzyme expression hence can be used as a promising drug cure damages.
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