Cholinesterase inhibitors ameliorate spatial learning deficits in rats following hypobaric hypoxia

摘要: Cognitive functions especially learning and memory are severely affected by high altitude (HA) exposure. Hypobaric hypoxia (HBH) encountered at HA is known to cause oxidative stress, alterations of neurotransmitters cognitive impairment. We hypothesized that alteration in cholinergic system may be involved HBH-induced The present study has investigated the dysfunctions associated with simulated impairment rats protective role acetylcholine esterase inhibitors (AChEIs). Male Sprague–Dawley were exposed HBH equivalent 6,100 m for 7 days a decompression chamber. After stipulated period exposure, ability was assessed using Morris water maze (MWM) task. Cholinergic markers like (ACh) acetyl cholinesterase (AChE) evaluated from cortex hippocampus. Morphological changes cortex, CA1, CA3 region hippocampus Nissle staining electron microscopy. found exposure led MWM task, it accompanied decrease ACh level, increase AChE activity, revealed critical cellular damage. Administration AChEIs physostigmine (PHY) galantamine (GAL) resulted amelioration deleterious effects induced HBH. also able restore neuronal morphology. Our data suggest HBH, improve rats.