Selective Serotonin Reuptake Inhibitors

作者: Frans de Jonghe , Jan Swinkels

DOI: 10.2165/00023210-199707060-00004

关键词: CitalopramFluoxetinePsychopharmacologyParoxetineFluvoxaminePharmacologyTolerabilityMedicineSertralineReuptake inhibitorPharmacology (medical)Psychiatry and Mental healthClinical neurology

摘要: In this article, we raise the following question regarding treatment of depression with selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs) citalopram, fluoxetine, fluvoxamine, paroxetine and sertraline: are there clinically relevant differences between these SSRIs in terms their (i) pharmacodynamic pharmacokinetic (ii) clinical (i.e. efficacy, tolerability, adverse events safety) profiles?

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