19F NMR of 2‐deoxy‐2‐fluoro‐D‐glucose for tumor diagnosis in mice. An NDP‐bound hexose analog as a new NMR target for imaging

摘要: A well-known radiopharmaceutical 2-deoxy-2-fluoro-D-glucose widely used for positron emission tomography diagnosis in terms of glucose utilization, was re-evaluated here as a nuclear magnetic resonance pharmaceutical cancer detection. The uptake and metabolism FDG the experimental tumor, MH134, transplanted to peritoneum C3H mice an ascitic tumor studied extensively by ex vivo 19 F NMR. Prolonged retention its metabolites over 2 days confirmed cells well heart. In these tissues, 6-phosphate injected compound converted reversibly epimer 2-deoxy-2-fluoro-D-mannose further their NDP bound forms. were almost cleared within day from other healthy organs where formation NDP-2-deoxy-2-fluoro-D-mannose low. Thus, NMR signal NDP-FDM detected 1 after injection could be target Through use spectra chemical shift images, feasibility this proposal demonstrated. It concluded that FDG-NMR has potential animals.