Hypospadias and early gestation growth restriction in infants.

摘要: Objective. There has been a major increase in the incidence of hypospadias infants 1990s, but risk factors are not known. Although there scattered reports literature regarding association low birth weight and hypospadias, this systematically studied. The objective study was to determine between early gestation intrauterine growth hypospadias. Methods. A retrospective review 13 years admissions 2 tertiary care neonatal intensive units (NI-CUs) Connecticut (1987-2000) showed that 112 (1.66%) 6746 male had any degree Of these, 8 were part genetic syndrome excluded. cohort analysis these 6738 performed. Infant parameters at (weight, head circumference, length) analyzed along with maternal known be associated changes fetal growth, including age, race, diagnosis preeclampsia, gestational diabetes, use alcohol or tobacco substance abuse during pregnancy. Results. NICU population increased 10-fold from 0.4% 1987 4% first quarter 2000. Hypospadias significantly more common who uniformly poor (<10th percentiles) various measured: weight, length, circumference. no significant differences age nor alcohol, tobacco, street drugs by mother. singletons multiple-gestation births. However, frequency occurrence higher among first-born (1.9%) compared all other (0.9%). Conclusions. our 13-year period study. growth. restriction probably cause as proportionate involvement somatic (weight brain (head circumference). increasing its originating suggests environmental factors) have an impact on both conditions may involved.