Increased level of thyroglobulin mRNA in a human familial goiter.
作者： A. Monticelli , V. E. Avvedimento , A. Mariano , C. Marcocci , L. Chiovato
DOI: 10.1007/BF03347155
关键词: Messenger RNA 、 Thyroid 、 Enzyme 、 Internal medicine 、 Endocrinology 、 Thyroglobulin 、 Stimulation 、 Gene expression 、 Familial goiter 、 Medicine 、 Goiter
摘要: Thyroglobulin (Tg) and its specific mRNA were analyzed in the thyroid gland of two cases familial goiter. A three-fold increase level stable protein functional Tg was found goiter one patients whom a desiodase defect demonstrated. Normal concentrations both other which no enzymatic could be shown. Our results suggest that levels with due to chronic stimulation by TSH.
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