Which SSRI? A meta-analysis of pharmacotherapy trials in pediatric obsessive-compulsive disorder.
作者： Daniel A. Geller , Joseph Biederman , S. Evelyn Stewart , Benjamin Mullin , Andrés Martin
DOI: 10.1176/APPI.AJP.160.11.1919
关键词: Clinical study design 、 Clomipramine 、 Sertraline 、 Meta-analysis 、 Fluoxetine 、 Anxiety disorder 、 Fluvoxamine 、 Clinical psychology 、 Paroxetine 、 Internal medicine 、 Psychology
摘要: OBJECTIVE: The authors conducted a meta-analysis of published randomized, controlled medication trials in children and adolescents with obsessive-compulsive disorder (OCD) to assess evidence for differential efficacy based on type drug, study design, outcome measure. METHOD: A systematic literature search was performed articles pertaining the pharmacological treatment pediatric and/or adolescent OCD. All baseline, posttreatment, change scores standard deviations reported each were included analyses. Effect sizes dependent measures expressed as standardized mean differences. analysis data four selective serotonin reuptake inhibitors (SSRIs) (paroxetine, fluoxetine, fluvoxamine, sertraline) clomipramine, designs, measures, two types (change posttreatment scores). Multivariate regression degree which effect varied the...
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