Monoamine transporters: vulnerable and vital doorkeepers.
作者： Zhicheng Lin , Juan J. Canales , Thröstur Björgvinsson , Morgane Thomsen , Hong Qu
DOI: 10.1016/B978-0-12-385506-0.00001-6
关键词:
摘要: Transporters of dopamine, serotonin, and norepinephrine have been empirically used as medication targets for several mental illnesses in the last decades. These protein-targeted medications are effective only subpopulations patients with transporter-related brain disorders. Since cDNA clonings early 1990s, molecular studies these transporters revealed a wealth information about transporters' structure-activity relationship (SAR), neuropharmacology, cell biology, biochemistry, pharmacogenetics, diseases related to human genes encoding among regulators. Such new creates unique opportunity develop transporter-specific based on SAR, mRNA, DNA, perhaps transporter trafficking regulation number highly relevant including substance abuse, depression, schizophrenia, Parkinson's disease.
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