Structure of the gene for a carbohydrate-binding receptor unique to rat kupffer cells.

作者: G W Hoyle , R L Hill

DOI: 10.1016/S0021-9258(18)52371-1

关键词: IntronGeneExonNucleic acid sequenceGABBR2Molecular biologyBiologyGABBR15-HT5A receptorCoding region

摘要: The gene encoding the rat Kupffer cell receptor for fucose and galactose (Lehrman, M. A., Hill, R. L. (1986) J. Biol. Chem. 261, 7419-7425 Lehrman, Haltiwanger, S., 7426-7432) has been isolated characterized. nucleotide sequence of 9.7-kilobase 1 kilobase 5'-flanking was determined. 5' end coding determined by primer extension S1 mapping transcript. Knowledge transcription start site allowed potential promoter elements to be identified. is encoded seven exons that are split six introns. divisions among domains in can correlated with gene. carbohydrate recognition domain three similar those hepatic lectin, human Fc IgE, cartilage proteoglycan core protein genes. A model evolution vertebrate lectin genes have analyzed presented.

参考文章(38)
T Tanaka, R Har-el, M L Tanzer, Partial structure of the gene for chicken cartilage proteoglycan core protein. Journal of Biological Chemistry. ,vol. 263, pp. 15831- 15835 ,(1988) , 10.1016/S0021-9258(19)37663-X
H Takahashi, H Komano, N Kawaguchi, N Kitamura, S Nakanishi, S Natori, Cloning and sequencing of cDNA of Sarcophaga peregrina humoral lectin induced on injury of the body wall. Journal of Biological Chemistry. ,vol. 260, pp. 12228- 12233 ,(1985) , 10.1016/S0021-9258(17)39014-2
D F Halberg, G Proulx, K Doege, Y Yamada, K Drickamer, A segment of the cartilage proteoglycan core protein has lectin-like activity. Journal of Biological Chemistry. ,vol. 263, pp. 9486- 9490 ,(1988) , 10.1016/S0021-9258(19)76567-3
M A Lehrman, R S Haltiwanger, R L Hill, The binding of fucose-containing glycoproteins by hepatic lectins. The binding specificity of the rat liver fucose lectin. Journal of Biological Chemistry. ,vol. 261, pp. 7426- 7432 ,(1986) , 10.1016/S0021-9258(17)38409-0
K Doege, M Sasaki, E Horigan, J R Hassell, Y Yamada, Complete primary structure of the rat cartilage proteoglycan core protein deduced from cDNA clones. Journal of Biological Chemistry. ,vol. 262, pp. 17757- 17767 ,(1987) , 10.1016/S0021-9258(18)45444-0