Integrating Brain Implants With Local and Distributed Computing Devices: A Next Generation Epilepsy Management System

作者: Vaclav Kremen , Benjamin H. Brinkmann , Inyong Kim , Hari Guragain , Mona Nasseri

DOI: 10.1109/JTEHM.2018.2869398

关键词: Cloud computingEpilepsyBrain implantBrain stimulationMobile deviceDeep brain stimulationEmbedded systemInterface (computing)Computer scienceElectrical brain stimulation

摘要: Brain stimulation has emerged as an effective treatment for a wide range of neurological and psychiatric diseases. Parkinson’s disease, epilepsy, essential tremor have FDA indications electrical brain using intracranially implanted electrodes. Interfacing implantable devices with local cloud computing resources the potential to improve efficacy, disease tracking, management. Epilepsy, in particular, is that might benefit from integration implants off-the-body tracking therapy. Recent clinical trials demonstrated seizure forecasting, detection, therapeutic patients drug-resistant focal epilepsy. In this paper, we describe next-generation epilepsy management system integrates handheld cloud-computing wirelessly coupled device embedded payloads (sensors, intracranial EEG telemetry, stimulation, classifiers, control policy implementation). The can provide seamless interface between physicians, realtime be used classify state (wake/sleep, preseizure, seizure), implement policies track patient health. This creates flexible platform which low demand analytics requiring fast response times are more complex algorithms implemented offthebody distributed environments. enables epileptic neural networks operating over time scales ranging milliseconds months.

参考文章(49)
Duane Bourget, Hank Bink, Scott Stanslaski, David Linde, Chris Arnett, Tom Adamski, Tim Denison, An implantable, rechargeable neuromodulation research tool using a distributed interface and algorithm architecture international ieee/embs conference on neural engineering. pp. 61- 65 ,(2015) , 10.1109/NER.2015.7146560
Benjamin H Brinkmann, Edward E Patterson, Charles Vite, Vincent M Vasoli, Daniel Crepeau, Matt Stead, J Jeffry Howbert, Vladimir Cherkassky, Joost B Wagenaar, Brian Litt, Gregory A Worrell, None, Forecasting Seizures Using Intracranial EEG Measures and SVM in Naturally Occurring Canine Epilepsy PLOS ONE. ,vol. 10, ,(2015) , 10.1371/JOURNAL.PONE.0133900
Kathryn A. Davis, Beverly K. Sturges, Charles H. Vite, Vanessa Ruedebusch, Gregory Worrell, Andrew B. Gardner, Kent Leyde, W. Douglas Sheffield, Brian Litt, A novel implanted device to wirelessly record and analyze continuous intracranial canine EEG. Epilepsy Research. ,vol. 96, pp. 116- 122 ,(2011) , 10.1016/J.EPLEPSYRES.2011.05.011
Kate Chandler, Canine epilepsy: what can we learn from human seizure disorders? Veterinary Journal. ,vol. 172, pp. 207- 217 ,(2006) , 10.1016/J.TVJL.2005.07.001
G.A. Worrell, K. Jerbi, K. Kobayashi, J.M. Lina, R. Zelmann, M. Le Van Quyen, Recording and analysis techniques for high-frequency oscillations Progress in Neurobiology. ,vol. 98, pp. 265- 278 ,(2012) , 10.1016/J.PNEUROBIO.2012.02.006
Janis Jeserevics, Ranno Viitmaa, Sigitas Cizinauskas, Kimmo Sainio, Tarja S. Jokinen, Marjatta Snellman, Claudio Bellino, Luciana Bergamasco, Electroencephalography Findings in Healthy and Finnish Spitz Dogs with Epilepsy : Visual and Background Quantitative Analysis Journal of Veterinary Internal Medicine. ,vol. 21, pp. 1299- 1306 ,(2007) , 10.1111/J.1939-1676.2007.TB01952.X
Matthew R. Sarkisian, Overview of the Current Animal Models for Human Seizure and Epileptic Disorders. Epilepsy & Behavior. ,vol. 2, pp. 201- 216 ,(2001) , 10.1006/EBEH.2001.0193
Christopher R. Butson, Georg Tamm, Sanket Jain, Thomas Fogal, Jens Krüger, Evaluation of Interactive Visualization on Mobile Computing Platforms for Selection of Deep Brain Stimulation Parameters IEEE Transactions on Visualization and Computer Graphics. ,vol. 19, pp. 108- 117 ,(2013) , 10.1109/TVCG.2012.92
S. Kalitzin, D. Velis, P. Suffczynski, J. Parra, F. Lopes da Silva, Electrical brain-stimulation paradigm for estimating the seizure onset site and the time to ictal transition in temporal lobe epilepsy. Clinical Neurophysiology. ,vol. 116, pp. 718- 728 ,(2005) , 10.1016/J.CLINPH.2004.08.021
Ilo E. Leppik, Edward Patterson, Brian Hardy, James C. Cloyd, Canine status epilepticus: Proof of principle studies. Epilepsia. ,vol. 50, pp. 14- 15 ,(2009) , 10.1111/J.1528-1167.2009.02362.X