DNA nanomapping using CRISPR-Cas9 as a programmable nanoparticle

作者: Andrey Mikheikin , Anita Olsen , Kevin Leslie , Freddie Russell-Pavier , Andrew Yacoot

DOI: 10.1038/S41467-017-01891-9

关键词: Physical mappingDNACRISPRDNA nanotechnologyGenomicsProof of conceptAtomic force microscopyComputational biologyDna geneticsComputer science

摘要: … Here, we report two technical advances in DNA nanotechnology and single-molecule genomics: (1) we describe a labeling technique (CRISPR-Cas9 nanoparticles) for high-speed AFM…

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