Programming for CD8 T Cell Memory Development Requires IL-12 or Type I IFN

摘要: Inflammation can have both positive and negative effects on development of CD8 T cell memory, but the relative contributions cellular targets cytokines involved are unclear. Using cells lacking receptors for IL-12, type I IFN, or both, we show that these act directly to support memory formation in response vaccinia virus Listeria monocytogenes infections. Development is supported predominantly by whereas IL-12 IFN contribute Listeria. In contrast formation, inability respond had a relatively small impact level primary expansion, with at most 3-fold reduction case responses We further programming complete within 3 days initial naive Ag. This does not result population expresses killer lectin-like receptor G1, majority resulting CD62Lhigh phenotype characteristic central cells. Consistent this, undergo strong expansion upon rechallenge provide protective immunity. These data demonstrate play an essential early role determining whether Ag encounter results population.