RADIOSENSITIZATION OF CANCER STEM CELLS: TARGETING TGFβ, NOTCH OR TELOMERASE TO IMPROVE TUMOR RESPONSE O RADIOTHERAPY

摘要: Radiation resistant cancer stem cells are the main reason for treatment failure and tumor recurrence after radiotherapy. Increasing biological evidences demonstrate that these possess capacity to repair radiation induced DNA damage, protect themselves from derived reactive oxygen species, survive proliferate several fractions of radiotherapy finally, repopulate heterogeneity tumor. Thus, targeting eliminating should be necessary achieve cure in Three major approaches specifically target radioresistant have been recently investigated. First, inhibition TGFβ, a mediator tissue response radiation, has shown induce radiosensitization by damage mechanism. Second, preventing Notch activation during fractionated radiotherapy, were depleted their ability radiation. Finally, telomerase activity inhibitors decrease cell population In present review, we evaluate radiosentitizing possible effects when combined with as they promise powerful tool battle against this cancer.