Percentage of free serum prostate-specific antigen: a new tool in the early diagnosis of prostatic cancer.
作者： M.-E. Toubert , J. Guillet , M. Chiron , P. Meria , C. Role
DOI: 10.1016/S0959-8049(96)00245-6
关键词:
摘要: Prostate-specific antigen (PSA) is a protease able to bind serum antiproteases as alpha 1 antichymotrypsin (ACT). Free PSA (FPSA) corresponds the fraction of total (TPSA) which unbound ACT. Specific detection FPSA seems be valuable tool in distinction between prostatic cancer (PCa) and benign hyperplasia (BPH). Our aim was evaluate retrospectively FPSA/TPSA ratio comparison TPSA or determination, using two new immunoradiometric assays (PSA-RIACT FPSA-RIACT, CIS bio international, Gif Sur Yvette, France) early diagnosis PCa. 256 men, with levels 0.7 44.7 ng/ml (median age = 69 years), including 164 sera obtained from patients BPH 92 untreated PCa were assayed. All diagnoses histologically confirmed tested before any adjuvant treatment. The evaluation median groups showed significantly different values (BPH group: 24.2%, 12.1%, P 10 ng/ml).
elsevier.com
sci-hub.se 参考文章(31)
William J. Ellis, Michael P. Chetner, Steven D. Preston, Michael K. Brawer, Diagnosis of Prostatic Carcinoma: The Yield of Serum Prostate Specific Antigen, Digital Rectal Examination and Transrectal Ultrasonography Journal of Urology. ,vol. 152, pp. 1520- 1525 ,(1994) , 10.1016/S0022-5347(17)32460-6
Alan W. Partin, Joseph E. Oesterling, The Clinical Usefulness of Prostate Specific Antigen: Update 1994 Journal of Urology. ,vol. 152, pp. 1358- 1368 ,(1994) , 10.1016/S0022-5347(17)32422-9
David W. Keetch, William J. Catalona, Deborah S. Smith, Serial prostatic biopsies in men with persistently elevated serum prostate specific antigen values The Journal of Urology. ,vol. 151, pp. 1571- 1574 ,(1994) , 10.1016/S0022-5347(17)35304-1
H Lilja, A Christensson, U Dahlén, M T Matikainen, O Nilsson, K Pettersson, T Lövgren, Prostate-specific antigen in serum occurs predominantly in complex with alpha 1-antichymotrypsin. Clinical Chemistry. ,vol. 37, pp. 1618- 1625 ,(1991) , 10.1093/CLINCHEM/37.9.1618
Anders christensson, Thomas Björk, Olle Nilsson, Ulrika Dahlén, Marja-Terttu Matikainen, Abraham T.K. Cockett, Per-Anders Abrahamsson, Hans Lilja, Serum Prostate Specific Antigen Complexed to α1-Antichymotrypsin as an Indicator of Prostate Cancer The Journal of Urology. ,vol. 150, pp. 100- 105 ,(1993) , 10.1016/S0022-5347(17)35408-3
James R. Anderson, Daniel Strickland, David Corbin, John A. Byrnes, B.S. Eugene Zweiback, Age-specific reference ranges for serum prostate-specific antigen. Urology. ,vol. 46, pp. 54- 57 ,(1995) , 10.1016/S0090-4295(99)80158-7
Peter J. Littrup, Prostate cancer screening : appropriate choices ? Cancer. ,vol. 74, pp. 2016- 2022 ,(1994) , 10.1002/1097-0142(19941001)74:7+<2016::AID-CNCR2820741705>3.0.CO;2-J
Takayoshi Demura, Nobuo Shinohara, Motoyoshi Tanaka, Nobuyasu Enami, Hitoshi Chiba, Masaki Togashi, Nobuo Ohashi, Katsuya Nonomura, Tomohiko Koyanagi, The proportion of free to total prostate specific antigen: A method of detecting prostate carcinoma Cancer. ,vol. 77, pp. 1137- 1143 ,(1996) , 10.1002/(SICI)1097-0142(19960315)77:6<1137::AID-CNCR20>3.0.CO;2-1
Joseph E. Oesterling, Steven J. Jacobsen, William H. Cooner, The Use of Age-Specific Reference Ranges for Serum Prostate Specific Anitgen in Men 60 years Old or Older The Journal of Urology. ,vol. 153, pp. 1160- 1163 ,(1995) , 10.1016/S0022-5347(01)67538-4
William J. Catalona, M’Liss A. Hudson, Peter T. Scardino, Jerome P. Richie, Frederick R. Ahmann, Robert C. Flanigan, Jean B. deKernion, Timothy L. Ratliff, Louis R. Kavoussi, Bruce L. Dalkin, W. Bedford Waters, Michael T. MacFarlane, Paula C. Southwick, Selection of Optimal Prostate Specific Antigen Cutoffs for Early Detection of Prostate Cancer: Receiver Operating Characteristic Curves Journal of Urology. ,vol. 152, pp. 2037- 2042 ,(1994) , 10.1016/S0022-5347(17)32300-5