Chronic antidepressant treatment accelerates kindling epileptogenesis in rats.
作者： Lisa Cardamone , Michael R. Salzberg , Amelia S. Koe , Ezgi Ozturk , Terence J. O'Brien
DOI: 10.1016/J.NBD.2013.11.020
关键词: Fluoxetine 、 Seizure threshold 、 Antidepressant 、 Epileptogenesis 、 Pharmacology 、 Status epilepticus 、 Citalopram 、 Medicine 、 Serotonin transporter 、 Epilepsy
摘要: Abstract Objectives Due to the high comorbidity of epilepsy and depression, antidepressant treatment is commonly indicated for patients with epilepsy. Studies in humans animal models suggest that selective serotonin reuptake inhibitors (SSRIs) may reduce seizure frequency severity, these drugs are generally considered safe use No studies have investigated effects SSRIs on epileptogenesis, neurobiological process underlying development epileptic state. Methods The effect continuous infusion SSRI, fluoxetine (10 mg/kg/day sc), versus vehicle control amygdala kindling was examined adult male Wistar rats. Seizure threshold rates were compared between SSRI-treated rats controls. study then repeated examining a different citalopram control. Hippocampal mRNA expression transporter (SERT) 5-HT 1A receptor brains post-mortem. Results Treatment either or significantly accelerated as evidenced by fewer stimulations reach Class V seizures their respective vehicle-treated group (p 0.05). analysis did not reveal any molecular changes which common both treatments. Conclusions rate epileptogenesis enhanced chronic SSRIs. This could potentially implications regarding progression human
doaj.org参考文章(49)
Mineo Takei, Tadashi Kurimoto, Isao Yokoi, Akitane Mori, Hideaki Kabuto, Atsushi Endo, Chronic administration of citalopram inhibited El mouse convulsions and decreased monoamine oxidase-A activity. Acta Medica Okayama. ,vol. 48, pp. 311- 316 ,(1994) , 10.18926/AMO/31102
Kajsa M. Igelström, Preclinical antiepileptic actions of selective serotonin reuptake inhibitors-Implications for clinical trial design Epilepsia. ,vol. 53, pp. 596- 605 ,(2012) , 10.1111/J.1528-1167.2012.03427.X
Loren H. Parsons, Tony M. Kerr, Laurence H. Tecott, 5-HT(1A) receptor mutant mice exhibit enhanced tonic, stress-induced and fluoxetine-induced serotonergic neurotransmission. Journal of Neurochemistry. ,vol. 77, pp. 607- 617 ,(2001) , 10.1046/J.1471-4159.2001.00254.X
L Cardamone, MR Salzberg, TJ O'Brien, NC Jones, Antidepressant therapy in epilepsy: can treating the comorbidities affect the underlying disorder? British Journal of Pharmacology. ,vol. 168, pp. 1531- 1554 ,(2013) , 10.1111/BPH.12052
William H. Theodore, Gregor Hasler, Giampiero Giovacchini, Kathleen Kelley, Pat Reeves-Tyer, Peter Herscovitch, Wayne Drevets, Reduced hippocampal 5HT1A PET receptor binding and depression in temporal lobe epilepsy. Epilepsia. ,vol. 48, pp. 1526- 1530 ,(2007) , 10.1111/J.1528-1167.2007.01089.X
Katia Vermoesen, Ann Massie, Ilse Smolders, Ralph Clinckers, The antidepressants citalopram and reboxetine reduce seizure frequency in rats with chronic epilepsy Epilepsia. ,vol. 53, pp. 870- 878 ,(2012) , 10.1111/J.1528-1167.2012.03436.X
Paul J. Goodnick, Burton J. Goldstein, Selective serotonin reuptake inhibitors in affective disorders -II. Efficacy and quality of life: Journal of Psychopharmacology. ,vol. 12, ,(1998) , 10.1177/0269881198012003031
Lakshmi Mynepalli, David J. Webb, John Weil, W. Allen Hauser, Dale C. Hesdorffer, Lianna Ishihara, Epilepsy, suicidality, and psychiatric disorders: a bidirectional association. Annals of Neurology. ,vol. 72, pp. 184- 191 ,(2012) , 10.1002/ANA.23601
Andres M. Kanner, Depression and Epilepsy: A Review of Multiple Facets of Their Close Relation Neurologic Clinics. ,vol. 27, pp. 865- 880 ,(2009) , 10.1016/J.NCL.2009.08.002
Ronald J Racine, Modification of seizure activity by electrical stimulation. I. After-discharge threshold. Electroencephalography and Clinical Neurophysiology. ,vol. 32, pp. 269- 279 ,(1972) , 10.1016/0013-4694(72)90176-9