Chronic administration of citalopram inhibited El mouse convulsions and decreased monoamine oxidase-A activity.

摘要: Serotonin (5-HT) is thought to play an important role in the seizures of El mice because seizure threshold correlates with 5-HT concentration central nervous system. In this study, anticonvulsant effect a reuptake blocker, citalopram, was evaluated behaviorally and biochemically. mouse convulsions were inhibited by chronic administration citalopram (80 mg/kg/day, p.o. for 2 weeks), but not acute mg/kg, i.p., h after single injection). Both decreased 5-hydroxyindolacetic acid brain, whereas changed treatment citalopram. Tryptophan hydroxylase activity different between control groups, although monoamine oxydase-A lowered These findings suggest that both depresses turnover rate, however necessary inhibit convulsions.