作者: Edward M. Brown
DOI: 10.1007/S00198-002-1343-6
关键词: Bone cell 、 Endocrinology 、 Medicine 、 Parathyroid chief cell 、 Calcitonin 、 Homeostasis 、 Osteoblast 、 Parathyroid hormone 、 Bone resorption 、 Calcium metabolism 、 Internal medicine
摘要: The extracellular calcium-sensing receptor (CaR) plays key roles in maintaining calcium homeostasis by enabling several of the cells and tissues involved this process to sense small changes Ca(2+)(o) respond with cellular function that will restore its normal level. chief parathyroid gland thyroidal C-cells, for example, decreases increased secretion Ca(2+)(o)-elevating hormone, hormone (PTH), decreased Ca(2+)(o)-lowering calcitonin, respectively. renal distal tubule are likewise capable sensing tubular reabsorption Ca(2+) vice versa, alterations contribute normalization Ca(2+)(o). skeleton also both osteoblasts osteoclasts can Ca(2+)(o), elevations promoting bone formation inhibiting resorption. It has been suggested Sr(2+) could act on via CaR; however, molecular mechanisms through which Sr(2+)(o) exert these actions remain controversial. Therefore, identifying their target(s) would have significant implications treatment loss. Ideally, therapies should simultaneously inhibit resorption while stimulating formation. Administration strontium produces exactly those effects. Previous studies dispersed bovine as well a preliminary study using CaR-transfected Chinese hamster ovary (CHO) indicate is an agonist CaR, albeit slightly lower efficacies potencies than Given distributed preferentially bone, therefore, action divalent cation CaR represents one possible mechanism ranelate, new antiosteoporotic drug, exerts it skeletal vivo.