The Calcium-Sensing Receptor Stimulates JNK in MDCK Cells
作者： John M. Arthur , Martha S. Lawrence , Cameron R. Payne , Madhavi J. Rane , Kenneth R. McLeish
关键词: JUN kinase 、 Stimulation 、 Kinase 、 Biology 、 Cell biology 、 Mitogen-activated protein kinase 、 G protein 、 Calcium-sensing receptor 、 Pertussis toxin 、 Receptor 、 Biophysics 、 Biochemistry 、 Molecular biology
摘要: The calcium-sensing receptor (CaR) stimulates ERK1 in rat fibroblasts, but its effect on other MAP kinases is not known. We used a model of renal distal tubule, the MDCK cell, to determine effects CaR stimulation Jun kinase (JNK) activity. Stimulation with 5 mM Ca2+ resulted time-dependent increase JNK Activation occurred preferentially basal surface relative apical surface. Basal administration agonist gadolinium (30 μm) also stimulated Pertussis toxin blocked ability both agonists stimulate JNK, indicating that was mediated through Giα class G proteins. Finally, we confocal microscopy located predominantly These studies demonstrate for first time
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