Molecular basis and evolution of multiple drug resistance in the foodborne pathogen Salmonella enterica serovar Ohio.
作者： Noelia Martínez , Irene Rodríguez , Rosaura Rodicio , María del Carmen Mendoza , María del Rosario Rodicio
关键词: Kanamycin 、 Serotype 、 Virology 、 Salmonella enterica 、 Multiple drug resistance 、 Molecular epidemiology 、 Microbiology 、 Ampicillin 、 Tetracycline 、 Biology 、 Integron
摘要: Abstract The molecular basis and evolution of multidrug resistance were established for 54 isolates Salmonella enterica serovar Ohio, recorded between 1991 2005 in Asturias, a northern region Spain. All closely related, as shown by cluster analysis XbaI-BlnI combined profiles. Of these, 33.3% resistant to one or more unrelated agent(s). Sulphonamides, streptomycin, tetracycline, trimethoprim, encoded sul1, aadA1, tet(A) tet(B), dfrA1, respectively, the most common resistances, but ampicillin (blaTEM-1), gentamicin (aacC2 aacC4), kanamycin (aphA1), chloramphenicol (catA1) also detected. Two types complex genetic elements, carried large conjugative mobilizable plasmids, found four agents (multidrug resistant), which accounted 18.5% total: (i) class 1 integron (1600 bp/dfrA1-aadA1) close defective Tn10, both inserted within Tn21-like element that was some case...
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