International collaborative studies on potency assays of diphtheria and tetanus toxoids

作者: A. S. Outschoorn , J. D. van Ramshorst , T. K. Sundaresan

DOI:

关键词: DiphtheriaToxoidDiphtheria toxinPotencyImmunologyTetanusDPT vaccineMedicineMedian lethal doseAntitoxin

摘要: Collaborative studies showed that relative potency assays for a particular type of diphtheria toxoid (adsorbed) and tetanus (plain adsorbed) gave very similar results, whether the were carried out by toxin challenge or antitoxin titration after immunization experimental animals with graded doses toxoid. The same numerical results obtained scoring system as based on survivals only. Although skin tests used limited scale in these studies, it seems likely they could replace lethal assays.For both diphtheria, adsorbed higher when combined other antigens than single Both mice guinea-pigs test For same, but (DPT vaccine) mouse assay about twice those guinea-pig assays.

参考文章(1)
Guy Bousfield, Lewis B. Holt, Violet Spiller, F. Croarke, Joan M. Barnes, A comparison of the antigenicity characteristics of mixed antigens in the child and the guinea-pig. Bulletin of The World Health Organization. ,vol. 20, pp. 1121- 1132 ,(1959)