Serum ceruloplasmin concentrations in rats with primary and transplanted sarcomas induced by nickel subsulfide
作者： Sunderman Fw , JM Mitchell , E Horak , Trudeau Ea , PR Allpass
DOI:
关键词: Pathology 、 Serum ceruloplasmin 、 Internal medicine 、 Chemistry 、 Oxidase test 、 Endocrinology 、 Ceruloplasmin 、 Liter 、 Alpha (ethology) 、 Tumor transplantation 、 Transplantation 、 Nickel Subsulfide
摘要: Ceruloplasmin (CPN) concentrations were measured by p-phenylenediamine oxidase assay in serums from (a) 30 control Fischer rats; (b) 5 rats with primary sarcomas induced i.m. injection of nickel subsulfide (alpha Ni3S2), and (c) 12 at intervals up to six weeks after s.c. transplantation four alpha Ni3S2-induced sarcomas. Serum CPN not significantly increased (mean = 0.38 g per liter) (S.D. +/- 0.05), versus 0.35 liter 0.04) controls. In contrast, serum within 11 21 days all transplanted Maximum occurred 31 34 tumor transplantation, 0.56 0.05 liter), equivalent 1.6 0.2 times the initial obtained prior treatment (P less than 0.001). The development hyperceruloplasminemia is attributed greatly enhanced growth-rates neoplasms.
参考文章(23)
Minghetti Pp, Maenza Rm, Lau Tj, Kasprzak Ks, Becker N, Sunderman Fw, Onkelinx C, Goldblatt Pj, Effects of manganese on carcinogenicity and metabolism of nickel subsulfide. Cancer Research. ,vol. 36, pp. 1790- 1800 ,(1976)
Hanna Ungar-Waron, Anita Gluckman, Mordechai Waron, Eliahu Spira, Ze'ev Trainin, Ceruloplasmin as a marker of neoplastic activity in rabbits bearing the VX-2 carcinoma. Cancer Research. ,vol. 38, pp. 1296- 1299 ,(1978)
Thomas J. Lau, F. William Sunderman, Lewis J. Cralley, Inhibitory effect of manganese upon muscle tumorigenesis by nickel subsulfide. Cancer Research. ,vol. 34, pp. 92- 95 ,(1974)
E. Pagliardi, E. Giangrandi, Clinical significance of the blood copper in Hodgkin's disease. Acta Haematologica. ,vol. 24, pp. 201- 212 ,(1960) , 10.1159/000206463
F.B. de Jorge, J.Sampaio Goes, J.L. Guedes, A.B. de Ulhoa Cintra, Biochemical studies on copper, copper oxidase, magnesium, sulfur, calcium and phosphorus in cancer of the breast Clinica Chimica Acta. ,vol. 12, pp. 403- 406 ,(1965) , 10.1016/0009-8981(65)90127-0
R.L. Warren, A.M. Jelliffe, J.V. Watson, C.B. Hobbs, Prolonged observations on variations in the serum copper in Hodgkin's disease Clinical Radiology. ,vol. 20, pp. 247- 256 ,(1969) , 10.1016/S0009-9260(69)80138-8
Carl F. Tessmer, Martin Hrgovcic, Forrest B. Thomas, Jordan Wilbur, David M. Mumford, Long-term serum copper studies in acute leukemia in children. Cancer. ,vol. 30, pp. 358- 365 ,(1972) , 10.1002/1097-0142(197208)30:2<358::AID-CNCR2820300209>3.0.CO;2-H
K W Pettingale, D E Tee, Serum protein changes in breast cancer: a prospective study. Journal of Clinical Pathology. ,vol. 30, pp. 1048- 1052 ,(1977) , 10.1136/JCP.30.11.1048
K. BjØrn Jensen, E. B. Thorling, C. J. Andersen, SERUM COPPER IN HODGKIN'S DISEASE. Scandinavian Journal of Haematology. ,vol. 1, pp. 63- 74 ,(2009) , 10.1111/J.1600-0609.1964.TB00006.X
S. H. Mortazavi, A. Bani-Hashemi, M. Mozafari, A. Raffi, Value of serum copper measurement in lymphomas and several other malignancies. Cancer. ,vol. 29, pp. 1193- 1198 ,(1972) , 10.1002/1097-0142(197205)29:5<1193::AID-CNCR2820290510>3.0.CO;2-6