Effect of endotoxins isolated from Desulfovibrio desulfuricans soil and intestinal strain on the secretion of TNF-alpha by human mononuclear cells
作者： Z. Dzierzewicz , B. Parfiniewicz , M. Jaworska-Kik , L Weglarz , Z. Kondera-Anasz
DOI:
关键词: Potency 、 Microbiology 、 Peripheral blood mononuclear cell 、 Inflammation 、 Salmonella 、 Bacteria 、 Biology 、 Lipopolysaccharide 、 Secretion 、 Tumor necrosis factor alpha
摘要: Mononuclear cells play an important role in the regulation of microbe-induced inflammation, part throughtheirabilitytosecretecytokinesinresponsetomicroorganismsandtheirproducts.�Toevaluatethe� effectsofDesulfovibrio desulfuricans-derived endotoxins on tnF-α induction, lipopolysaccharides (lpss) isolatedfromsoilandintestinalstrainwereusedtostimulateperipheralbloodmononuclearcells.� Theeffect� oftheselPSswasassessedincomparisontothatoflPSsfromEscherichia coli, Salmonella minnesota� andoflipidAfromSalmonellaminnesota. level was measured by enzyme-linked immunosor - bentassay.�D.�desulfuricans lpss at highest dose (1000 ng/ml) displayed greater biological potency inducing secretion than other used which indicates that these may act as a critical regulatoryfactorinbacteremiacausedbythesemicroorganisms.
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