Frequent administration by inhalation of salbutamol and ipratropium bromide in the initial management of severe acute asthma in children

摘要: A study was performed to compare the efficacy and safety of two therapeutic regimens for treatment children presenting emergency department with acute asthma. regimen inhaled salbutamol alone compared combined ipratropium bromide. Twenty-five ranging in age from 5 15 years were enrolled study. Children FEV1 less than or equal 55% predicted eligible participate Subjects randomized a double-blind fashion into one groups. Both groups received an initial dose by nebulizer 150 micrograms/kg (0.03 cc/kg), followed six consecutive doses 50 (0.01 cc/kg) at 20-minute intervals. In group subjects, 250 micrograms (1.0 ml) bromide respirator solution added administered time inhalation, 40 80 minutes, whereas remaining subjects placebo those times. Formal one-way statistical ANOVA change percent as response variable confirmed there statistically significant difference all points caused drug during 150-minute observation period. There no side effects reported Significant additional bronchodilation achieved together indicates that is likely substantial cholinergic element bronchospasm observed exacerbations asthma pediatric group.