Early detection of nasopharyngeal carcinoma by plasma Epstein-Barr virus DNA analysis in a surveillance program.

摘要: BACKGROUND: Nasopharyngeal carcinoma (NPC) is prevalent in Southeast Asia. Over the last decade, plasma Epstein-Barr virus (EBV) DNA has been developed as a tumor marker for NPC. In this study, authors investigated whether EBV analysis useful NPC surveillance. METHODS: In total, 1318 volunteers ages 40 to 60 years were prospectively recruited. Plasma and serology viral capsid antigen immunoglobulin A (IgA) measured. Participants who had detectable or positive IgA underwent nasal endoscopic examination follow-up approximately 2 weeks. All participants followed record development of NPC. RESULTS: Three individuals with identified at enrolment. them remained analysis. Only 1 those patients was serology. patient small confined mucosa, not on examination. Because 2-fold increase analysis, that magnetic resonance imaging, which revealed tumor. Among did have but initially results, 66% negative results after median weeks. CONCLUSIONS: Plasma proved detecting early without clinical suspicion Repeating test differentiated from false-positive results. Cancer 2013. © 2013 American Society.