Whole Blood Transcriptome and Other Biomarkers in Nasopharyngeal Cancer

摘要: Nasopharyngeal carcinoma is often diagnosed only after the disease has reached late stages and prognosis poor. However, when detected early, highly survivable. This review surveys molecular biomarker studies that aim to identify presymptomatic disease, predict response treatment, indicate prognosis, tumor stage, monitor progression. Blood transcriptomic represent a new frontier in diagnostics of nasopharyngeal carcinoma. List Abbreviations AUC Area Under Curve BCR B-cell Receptor CR Complete Response Treatment CT Computed Tomography DNA Deoxyribonucleic Acid EBV Epstein-Barr Virus EGFR1 Epidermal Growth Factor 1 ELISA Enzyme-Linked Immunosorbent Assay GWAS Genome-Wide Association Study HLA Human Leukocyte Antigen IgA Immunoglobulin A IgG G MHC Major Histocompatibility Complex miRNA MicroRNA MRI Magnetic Resonance Imaging mRNA Messenger RNA NPC Carcinoma PCR Polymerase Chain Reaction PR Partial Ribonucleic ROC Receiver Operating Characteristic SELDI-TOFMS Surface-Enhanced Laser Desorption Ionization-Time-of-Flight Mass Spectrometry Chun Ren Lim Michelle Lee contributed equally this manuscript *Email: cliew@genenews.com Biomarkers Cancer DOI 10.1007/978-94-007-7744-6_3-1 # Springer Science+Business Media Dordrecht 2014