Do Genetic Modifiers of High-Density Lipoprotein Cholesterol and Triglyceride Levels Also Modify Their Response to a Lifestyle Intervention in the Setting of Obesity and Type-2 Diabetes Mellitus? The Action for Health in Diabetes (Look AHEAD) Study

摘要: Background— High-density lipoprotein cholesterol (HDL-C) and triglycerides are cardiovascular risk factors susceptible to lifestyle behavior modification genetics. We hypothesized that genetic variants identified by genome-wide association studies as associated with HDL-C or triglyceride levels modify 1-year treatment response an intensive intervention, relative a usual care of diabetes mellitus support education. Methods Results— evaluated 82 single-nucleotide polymorphisms, which represent 31 loci demonstrated be triglycerides, in 3561 participants who consented for met eligibility criteria. Variants higher baseline levels, ester transfer protein ( CETP ) rs3764261 hepatic lipase LIPC rs8034802, were found increases intervention P =0.0038 0.013, respectively) had nominally significant interactions =0.047 0.046, respectively). The fatty acid desaturase-2 rs1535 variant, low =0.017), was (0.0037) nominal interaction =0.035). Apolipoprotein B (rs693) (rs8034802) polymorphisms showed associations changes <0.05). Phosphatidylglycerophosphate synthase-1 (rs4082919) the most full cohort =0.0009). Conclusions— This is first study identify modifying lipid responses randomized overweight obese individuals mellitus. effects on may differ from lipids modifiable behavioral intervention.