Genomic-based tools for the risk assessment, management, and prevention of type 2 diabetes

摘要: Type 2 diabetes (T2D) is a common and serious disorder significant risk factor for the development of cardiovascular disease, neuropathy, nephropathy, retinopathy, periodontal foot ulcers amputations. The burden disease associated with T2D has led to an emphasis on early identification millions individuals at high so that management intervention strategies can be effectively implemented before progression begins. With increasing knowledge about genetic basis T2D, several genomic-based have been tested their ability improve assessment, prevention. Genetic scores developed intent more accurately identify those potentially motivation adherence lifestyle modification programs. In addition, evidence building oral antihyperglycemic medications are subject pharmacogenomic variation in substantial number patients, suggesting genomics may soon play role determining most effective therapies. complex affects differently, prediction treatment challenging health care providers. Genomic approaches hold promise potential tailor individual patients contribute better outcomes T2D.