Resolution of derivatives of 1,2-propanediol with lipase B from Candida antarctica. Effect of substrate structure, medium, water activity and acyl donor on enantiomeric ratio.
作者： Thorleif Anthonsen , Bård Helge Hoff
DOI: 10.1016/S0009-3084(98)00043-7
关键词: Solvent effects 、 Water activity 、 Stereochemistry 、 Substrate (chemistry) 、 Chemistry 、 Propanediol 、 Candida antarctica 、 Hydrolysis 、 Organic chemistry 、 Equilibrium constant 、 Enantiomer
摘要: Abstract The glycerol-related racemic derivatives 1a–15a and 1b–15b have been resolved by hydrolysis transesterifications using lipase B from Candida antarctica. Influence of substrate structure for the enantiomeric ratio E has explained on basis previous molecular modelling. values equilibrium constants Keq calculated ees eep measured throughout reaction, ping-pong bi-bi mechanism computer program EK however, latter gave irreversible conditions.
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