Idiotypic and anti-idiotypic B-B cell interaction is controlled by major histocompatibility complex-restricted regulation

摘要: We have previously reported that the immunization of BALB/c mice with MOPC-104E myeloma protein (M104E) induced idiotype-specific Ly 1-negative B lymphocytes had an ability to enhance idiotype-positive anti-dextran antibody production. It was also shown cell interaction between idiotypic and anti-idiotypic observed in a class II-restricted manner. The effect monoclonal anti-class II on B-B is investigated this report. addition anti-I-A or anti-I-E into system, from both (H-2d) BALB.K (H-2k), inhibited enhanced production mediated by idiotype-immune lymphocytes. Interestingly, however, it revealed antibodies acted differently each B-lymphocyte population. Pretreatment (idiotype-immune) enhancing population diminished its activity, while did not. On other hand, pretreatment dextran-immune producing cells showed no effect, When F1 treated specific for one their parents' haplotypes, co-operation respective haplotype inhibited, but inhibitory could only be seen at early phase culture period. Taken together, results these experiments suggest antigens are concerned self-recognitive among frame idiotype network systems.