Factors that determine the occurrence of reperfusion arrhythmias

摘要: The determinants of reperfusion arrhythmias were investigated in 63 open-chest dogs undergoing a 25-minute coronary artery occlusion followed by reperfusion. Heart rate correlated positively with the occurrence ventricular tachycardia (VT) and fibrillation (VF). Collateral flow during ischemia (radioactive microspheres) exhibited strong negative correlation incidence both VT VF upon Importantly, sensitive coupling was present, whereby small differences associated large rhythm disorders. rise intramyocardial CO2 tension (another index severity ischemia) greater exhibiting (p < 0.001) 0.08); however, this variable significantly collateral (r = −0.57, p 0.01). size occluded bed, cetermined postmortem perfusion, not consistently related to VT; within given range bed sizes, inversely flow. Thus, reperfusion-induced is relatively independent determined primarily degree myocardial hypoperfusion. In contrast, did develop beds 25% left mass; above critical size, its perfusion. Reperfusion therefore association poor This study identifies systematically analyzes three major arrhythmias: (1) antecedent ischemia, estimated either from reduction or intramural tension; (2) amount ischemic/reperfused myocardium; (3) heart rate. addition conceptual interest clinical implications, findings have important implications for design future studies aimed at evaluating antiarrhythmic interventions experimental models.