Clinicopathological features of small nonfunctioning pancreatic neuroendocrine tumors

作者: Mariko Furukori , Koji Imai , Hidenori Karasaki , Kenji Watanabe , Kensuke Oikawa

DOI: 10.3748/WJG.V20.I47.17949

关键词: Predictive value of testsPathologyLymph nodeLymphadenectomyMalignancyClinicopathological featuresRetrospective cohort studyNeuroendocrine tumorsPancreatectomyMedicine

摘要: AIM: To present our experiences in studying the clinicopathological features of small nonfunctioning pancreatic neuroendocrine tumors (NF-pNETs). METHODS: The subjects included 9 patients with NF-pNETs who underwent pancreatectomy between April 1996 and September 2012. surgical procedure, histopathological findings, prognosis were assessed. RESULTS: All incidentally detected by computed tomography. median diameter was 10 mm (5-32 mm). One patient diagnosed von Hippel-Lindau disease, others sporadic cases. For 7 G1; 1 G2; patient, whose tumor 22 mm, had carcinoma (NEC). a that 32 direct invasion to regional lymph node NEC, metastases. Six NF-pNETs, excluding smaller than mm. Tumors showed no malignancy lacked metastasis. CONCLUSION: Sporadic tend have less malignant potential. These findings suggest lymphadenectomy may be omitted for after further investigation.

参考文章(28)
Naoki Ikenaga, Koji Yamaguchi, Hiroyuki Konomi, Kei Fujii, Atsushi Sugitani, Masao Tanaka, A minute nonfunctioning islet cell tumor demonstrating malignant features Journal of Hepato-biliary-pancreatic Surgery. ,vol. 12, pp. 84- 87 ,(2005) , 10.1007/S00534-004-0938-Z
Yassar M. Hashim, Kathryn M. Trinkaus, David C. Linehan, Steven S. Strasberg, Ryan C. Fields, Dengfeng Cao, William G. Hawkins, Regional lymphadenectomy is indicated in the surgical treatment of pancreatic neuroendocrine tumors (PNETs). Annals of Surgery. ,vol. 259, pp. 197- 203 ,(2014) , 10.1097/SLA.0000000000000348
Jan Franko, Wentao Feng, Linwah Yip, Elizabeth Genovese, A. James Moser, Non-functional neuroendocrine carcinoma of the pancreas: incidence, tumor biology, and outcomes in 2,158 patients. Journal of Gastrointestinal Surgery. ,vol. 14, pp. 541- 548 ,(2010) , 10.1007/S11605-009-1115-0
Carmen C. Solorzano, Jeffrey E. Lee, Peter W.T. Pisters, J.Nicolas Vauthey, G.Dan Ayers, Marina E. Jean, Robert F. Gagel, Jaffer A. Ajani, Robert A. Wolff, Douglas B. Evans, Nonfunctioning islet cell carcinoma of the pancreas: survival results in a contemporary series of 163 patients. Surgery. ,vol. 130, pp. 1078- 1085 ,(2001) , 10.1067/MSY.2001.118367
Kosuke Tsutsumi, Takao Ohtsuka, Yasuhisa Mori, Minoru Fujino, Takaharu Yasui, Shinichi Aishima, Shunichi Takahata, Masafumi Nakamura, Tetsuhide Ito, Masao Tanaka, Analysis of lymph node metastasis in pancreatic neuroendocrine tumors (PNETs) based on the tumor size and hormonal production. Journal of Gastroenterology. ,vol. 47, pp. 678- 685 ,(2012) , 10.1007/S00535-012-0540-0
Jun Chul Chung, Dong Wook Choi, Sung Ho Jo, Jin Seok Heo, Seong Ho Choi, Yong Il Kim, Malignant Nonfunctioning Endocrine Tumors of the Pancreas: Predictive Factors for Survival after Surgical Treatment World Journal of Surgery. ,vol. 31, pp. 579- 585 ,(2007) , 10.1007/S00268-006-0585-4
Asima Cheema, Jill Weber, Jonathan R. Strosberg, Incidental Detection of Pancreatic Neuroendocrine Tumors: An Analysis of Incidence and Outcomes Annals of Surgical Oncology. ,vol. 19, pp. 2932- 2936 ,(2012) , 10.1245/S10434-012-2285-7
Karl Y. Bilimoria, Mark S. Talamonti, James S. Tomlinson, Andrew K. Stewart, David P. Winchester, Clifford Y. Ko, David J. Bentrem, Prognostic score predicting survival after resection of pancreatic neuroendocrine tumors: analysis of 3851 patients. Annals of Surgery. ,vol. 247, pp. 490- 500 ,(2008) , 10.1097/SLA.0B013E31815B9CAE
Henning Dralle, Sabine L. Krohn, Wolfram Karges, Bernhard O. Boehm, Michael Brauckhoff, Oliver Gimm, Surgery of resectable nonfunctioning neuroendocrine pancreatic tumors. World Journal of Surgery. ,vol. 28, pp. 1248- 1260 ,(2004) , 10.1007/S00268-004-7609-8
Franz Sellner, Sabine Thalhammer, Stefan Stättner, Josef Karner, Martin Klimpfinger, TNM stage and grade in predicting the prognosis of operated, non-functioning neuroendocrine carcinoma of the pancreas--a single-institution experience. Journal of Surgical Oncology. ,vol. 104, pp. 17- 21 ,(2011) , 10.1002/JSO.21889