作者: Claudia Cannavo , Justin Tosh , Elizabeth M.C. Fisher , Frances K. Wiseman
DOI: 10.1016/BS.PBR.2019.10.004
关键词: Trisomy 、 Dementia 、 Context (language use) 、 Disease 、 Chromosome 21 、 Disease mechanisms 、 Medicine 、 Bioinformatics 、 Clinical research 、 Down syndrome
摘要: People who have Down syndrome are at significantly elevated risk of developing early onset Alzheimer's disease that causes dementia (AD-DS). Here we review recent progress in modeling the development AD-DS mouse models. These studies provide insight into mechanisms underlying and generate new clinical research questions. In addition, they suggest potential targets for prevention therapies.