Accelerated degradation behaviour of poly(ɛ-caprolactone) via melt blending with poly(aspartic acid-co-lactide) (PAL)
作者： Uel Little , Fraser Buchanan , Eileen Harkin-Jones , Mervyn McCaigue , David Farrar
DOI: 10.1016/J.POLYMDEGRADSTAB.2008.11.001
关键词: Polymer blend 、 Biocompatibility 、 Degradation (geology) 、 Biodegradation 、 Biomaterial 、 Chemical engineering 、 Lactide 、 Polycaprolactone 、 Polymer chemistry 、 Materials science 、 Polymer
摘要: Abstract Poly(ɛ-caprolactone) (PCL) has many favourable attributes for tissue engineering scaffold applications. A major drawback, however, is its slow degradation rate, typically greater than 3 years. In this study PCL was melt blended with a small percentage of poly(aspartic acid-co-lactide) (PAL) and the behaviour evaluated in phosphate buffer solution (PBS) at 37 °C. The addition PAL found to significantly enhance profile PCL. Subsequent investigated terms polymer's mechanical properties, molecular weight (Mw), mass changes thermal characteristics. results indicate that accelerates PCL, 20% loss recorded after just 7 months vitro samples containing 8 wt% PAL. corresponding pure exhibited no over same time period. assessment PCL/PAL composites culture medium absence cells revealed stable pH readings time. SEM studies cell/biomaterial interactions demonstrated biocompatibility C3H10T1/2 all concentrations additive.
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