Mapping Tissue Optical Attenuation to Identify Cancer Using Optical Coherence Tomography

作者: Robert A. McLaughlin , Loretta Scolaro , Peter Robbins , Christobel Saunders , Steven L. Jacques

DOI: 10.1007/978-3-642-04271-3_80

关键词: LymphLymphatic systemLymph nodeAttenuationCancerOptical coherence tomographyComputer scienceAttenuation coefficientBiomedical engineeringAxillary lymph nodes

摘要: The lymphatic system is a common route for the spread of cancer and identification lymph node metastases key task during surgery. This paper demonstrates use optical coherence tomography to construct parametric images nodes. It describes method automatically estimate attenuation coefficient tissue. By mapping at each location in scan, it possible image indicating variations tissue type. algorithm applied ex vivo samples human axillary nodes validated against histological gold standard. Results are shown illustrating variation properties between cancerous healthy

参考文章(13)
Handbook of optical coherence tomography Published in <b>2002</b> in New York by Marcel Dekker. ,(2001) , 10.1201/B14024
Ravikant Samatham, Steven L. Jacques, Paul Campagnola, Optical properties of mutant versus wild-type mouse skin measured by reflectance-mode confocal scanning laser microscopy (rCSLM). Journal of Biomedical Optics. ,vol. 13, pp. 041309- ,(2008) , 10.1117/1.2953195
G. Yoon, A. Welch, M. Motamedi, M.v. Gemert, Development and application of three-dimensional light distribution model for laser irradiated tissue IEEE Journal of Quantum Electronics. ,vol. 23, pp. 1721- 1733 ,(1987) , 10.1109/JQE.1987.1073224
C Rebecca Simpson, Matthias Kohl, Matthias Essenpreis, Mark Cope, Near-infrared optical properties ofex vivohuman skin and subcutaneous tissues measured using the Monte Carlo inversion technique Physics in Medicine and Biology. ,vol. 43, pp. 2465- 2478 ,(1998) , 10.1088/0031-9155/43/9/003
H Key, E R Davies, P C Jackson, P N T Wells, Optical attenuation characteristics of breast tissues at visible and near-infrared wavelengths. Physics in Medicine and Biology. ,vol. 36, pp. 579- 590 ,(1991) , 10.1088/0031-9155/36/5/002
Jianan Qu, Calum MacAulay, Stephen Lam, Branko Palcic, Optical properties of normal and carcinomatous bronchial tissue. Applied Optics. ,vol. 33, pp. 7397- 7405 ,(1994) , 10.1364/AO.33.007397
J. M. Schmitt, S. H. Xiang, K. M. Yung, Speckle in Optical Coherence Tomography Journal of Biomedical Optics. ,vol. 4, pp. 95- 105 ,(1999) , 10.1117/1.429925
Brian W. Pogue, Michael S. Patterson, Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry Journal of Biomedical Optics. ,vol. 11, pp. 041102- ,(2006) , 10.1117/1.2335429
T. Collier, D. Arifler, A. Malpica, M. Follen, R. Richards-Kortum, Determination of epithelial tissue scattering coefficient using confocal microscopy IEEE Journal of Selected Topics in Quantum Electronics. ,vol. 9, pp. 307- 313 ,(2003) , 10.1109/JSTQE.2003.814413
Tom Collier, Michele Follen, Anais Malpica, Rebecca Richards-Kortum, Sources of scattering in cervical tissue: determination of the scattering coefficient by confocal microscopy. Applied Optics. ,vol. 44, pp. 2072- 2081 ,(2005) , 10.1364/AO.44.002072